- Algeria
- President: Abdelmadjid Tebboune
- First Lady: Mary Tebboune
- Angola
- President: João Lourenço
- First Lady: Ana Dias Lourenço
- Benin
- President: Patrice Talon
- First Lady: Claudine Talon
- Botswana
- President: Mokgweetsi Masisi
- First Lady: Neo Masisi
- Burkina Faso
- President: Roch Marc Christian Kaboré
- First Lady: Adjoavi Sika Kabore
- Burundi
- President: Évariste Ndayishimiye
- First Lady: Angeline Ndayishimiye
- Cabo Verde (Cape Verde)
- President: José Maria Neves
- First Lady: Lígia Fonseca (wife of former President Jorge Carlos Fonseca)
- Cameroon
- President: Paul Biya
- First Lady: Chantal Biya
- Central African Republic (CAR)
- President: Faustin-Archange Touadéra
- First Lady: Brigitte Touadéra
- Chad
- President: Mahamat Déby Itno (following the death of Idriss Déby in April 2021, transitional period as of my last update)
- First Lady: Hinda Déby Itno (wife of former President Idriss Déby)
- Comoros
- President: Azali Assoumani
- First Lady: Mariam Azali Assoumani
- Democratic Republic of the Congo (DRC)
- President: Félix Tshisekedi
- First Lady: Denise Nyakeru Tshisekedi
- Djibouti
- President: Ismaïl Omar Guelleh
- First Lady: Kadra Mahamoud Haid
- Egypt
- President: Abdel Fattah el-Sisi
- First Lady: Entissar Amer
- Equatorial Guinea
- President: Teodoro Obiang Nguema Mbasogo
- First Lady: Constancia Mangue de Obiang
- Eritrea
- President: Isaias Afwerki
- First Lady: Saba Haile
- Eswatini (formerly Swaziland)
- King: Mswati III (as of January 2022, Eswatini is a monarchy)
- Queen Mother: Ntombi Tfwala (Mother of King Mswati III)
- Ethiopia
- Prime Minister: Abiy Ahmed
- First Lady: Zinash Tayachew
- Gabon
- President: Ali Bongo Ondimba
- First Lady: Sylvia Bongo Ondimba
- Gambia
- President: Adama Barrow
- First Lady: Fatou Bah-Barrow
- Ghana
- President: Nana Akufo-Addo
- First Lady: Rebecca Akufo-Addo
- Guinea
- President: Alpha Condé
- First Lady: Djene Kaba Condé
- Guinea-Bissau
- President: Umaro Sissoco Embaló
- First Lady: Rosa Teixeira Goudiaby Vaz
- Ivory Coast (Côte d’Ivoire)
- President: Alassane Ouattara
- First Lady: Dominique Ouattara
- Kenya
- President: William Ruto
- First Lady: Rachael Ruto
- Lesotho
- King: Letsie III (as of January 2022, Lesotho is a monarchy)
- Queen: ‘Masenate Mohato Seeiso
- Liberia
- President: George Weah
- First Lady: Clar Marie Weah
- Libya
- Interim Prime Minister: Abdul Hamid Dbeibeh (as of January 2022, Libya was in a transitional phase)
- First Lady: Safia Farkash (widow of former President Muammar Gaddafi)
- Madagascar
- President: Andry Rajoelina
- First Lady: Mialy Rajoelina
- Malawi
- President: Lazarus Chakwera
- First Lady: Monica Chakwera
- Mali
- Interim President: Assimi Goïta (as of January 2022, Mali was in a transitional phase)
- First Lady: Assimi Goïta
- Mauritania
- President: Mohamed Ould Ghazouani
- First Lady: Marieme Ghazouani
- Mauritius
- Prime Minister: Pravind Jugnauth (as of January 2022, Mauritius is a parliamentary republic)
- First Lady: Kobita Jugnauth
- Morocco
- King: Mohammed VI (as of January 2022, Morocco is a monarchy)
- Consort: Lalla Salma (former wife of King Mohammed VI)
- Mozambique
- President: Filipe Nyusi
- First Lady: Isaura Nyusi
- Namibia
- President: Hage Geingob
- First Lady: Monica Geingos
- Niger
- President: Mohamed Bazoum
- First Lady: Lalla Malika Issoufou
- Nigeria
- President: Muhammadu Buhari
- First Lady: Aisha Buhari
Home First Lady African countries along with their current presidents and their respective wives or First Ladies